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C4292

Sigma-Aldrich

Cefoperazone sodium salt

870 - 1015 μg/mg anhydrous basis

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About This Item

Fórmula empírica (notación de Hill):
C25H26N9NaO8S2
Número de CAS:
62893-20-3
Peso molecular:
667.65
Beilstein:
4902135
Número CE:
263-751-5
Número MDL:
MFCD07793331
Código UNSPSC:
51102829
ID de la sustancia en PubChem:
24892686
NACRES:
NA.85

Nivel de calidad

200

Análisis

870-1015 μg/mg (anhydrous basis)

formulario

powder or crystals

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

Modo de acción

cell wall synthesis | interferes

temp. de almacenamiento

2-8°C

cadena SMILES

[Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C([O-])=O)c5ccc(O)cc5)C(=O)C1=O

InChI

1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1

Clave InChI

NCFTXMQPRQZFMZ-WERGMSTESA-M

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Descripción general

Chemical structure: ß-lactam

Aplicación

Cefoperazone is used to study drug-protein binding, expression and inhibition of penicillin-binding proteins (PBPs) during cell wall synthesis.

Acciones bioquímicas o fisiológicas

Cefoperazone exerts its bactericidal effect by inhibiting the mucopeptide synthesis that affects the structure of bacterial cell wall. It has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H317,H334

Consejos de prudencia

P261 - P280 - P342 + P311

Clasificaciones de peligro

Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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B Gonik et al.
Antimicrobial agents and chemotherapy, 30(6), 874-876 (1986-12-01)
Limited pharmacokinetic data for cefoperazone are available from the parturient. Because cefoperazone has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney, pregnancy-induced physiologic alterations can influence its deposition and clearance. Twelve term parturients receiving
A Meulemans
Antimicrobial agents and chemotherapy, 36(2), 295-298 (1992-02-01)
The apparent diffusion coefficient of a bound drug, cefoperazone, was studied. The protein binding of cefoperazone was studied by voltammetry, a technique which permitted instant measurements. The apparent diffusion coefficients were similar in agar and fibrin and lower in rat
Andrea T Fessler et al.
Veterinary microbiology, 157(1-2), 226-231 (2011-12-23)
The correct assessment of mastitis pathogens for their susceptibility/resistance to cefoperazone is currently hampered by the lack of harmonized test conditions and interpretive criteria. The aim of this study was to provide a proposal for clinical breakpoints of cefoperazone which
Jung-Whan Chon et al.
Applied and environmental microbiology, 78(5), 1624-1626 (2012-01-03)
Modified charcoal-cefoperazone-deoxycholate agar (mCCDA) was improved by supplementation with a high concentration of polymyxin B. The ability of the supplemented medium to isolate Campylobacter jejuni and C. coli from chicken carcass rinses was compared to that of Campy-Cefex agar and
Ke Ni et al.
PloS one, 7(7), e41104-e41104 (2012-07-31)
Regulatory T cells (Treg cells), which are essential for regulation of immune response to respiratory syncytial virus (RSV) infection, are promoted by pharyngeal commensal pneumococcus. The effects of pharyngeal microflora disruption by antibiotics on airway responsiveness and relative immune responses
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