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Sigma-Aldrich

CNQX disodium salt hydrate

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

Sinónimos:

6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

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About This Item

Fórmula empírica (notación de Hill):
C9H2N4Na2O4 · xH2O
Número de CAS:
115066-14-3
Peso molecular:
276.12 (anhydrous basis)
Número MDL:
MFCD09953908
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24277972
NACRES:
NA.77

product name

CNQX disodium salt hydrate, ≥98% (HPLC), solid

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

solid

condiciones de almacenamiento

protect from light

color

orange to red

solubilidad

H2O: >2 mg/mL (warmed)

cadena SMILES

O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O

InChI

1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2

Clave InChI

LCDWHGXMFAZHEO-UHFFFAOYSA-L

Información sobre el gen

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Aplicación

CNQX disodium salt hydrate has been used as:
  • as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
  • as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
  • as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Acciones bioquímicas o fisiológicas

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.
Potent, competitive AMPA/kainate receptor antagonist.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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CNQX Blocks Kainate-induced Corneal Irritation
Ibitokun, Bernadette O and Miller, Kenneth E
investigate opthalmology and visual science, 53(14), 1855-1855 (2012)
Vincent Villette et al.
Cell, 179(7), 1590-1608 (2019-12-14)
Optical interrogation of voltage in deep brain locations with cellular resolution would be immensely useful for understanding how neuronal circuits process information. Here, we report ASAP3, a genetically encoded voltage indicator with 51% fluorescence modulation by physiological voltages, submillisecond activation
Medicinal chemistry of competitive kainate receptor antagonists
Larsen, Ann M and Bunch, Lennart
ACS Chemical Neuroscience, 2(2), 60-74 (2010)
Teri M Furlong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 5012-5022 (2014-04-04)
Access to highly palatable and calorically dense foods contributes to increasing rates of obesity worldwide. Some have made the controversial argument that consumption of such foods can lead to "food addiction," yet little is known about how long-term access to
Maxime Lemieux et al.
PLoS biology, 17(4), e2003880-e2003880 (2019-04-25)
Because of their intermediate position between supraspinal locomotor centers and spinal circuits, gigantocellular reticular nucleus (GRN) neurons play a key role in motor command. However, the functional contribution of glutamatergic GRN neurons in initiating, maintaining, and stopping locomotion is still
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