C221

Carboxy-PTIO potassium salt

• Sinónimos: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt, 2-(4-Carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazol-1-yloxy-3-oxide potassium salt
• Fórmula empírica (notación de Hill): C₁₄H₁₆KN₂O₄
• Número de CAS: 148819-94-7
• Peso molecular: 315.39
• Número MDL: MFCD00216153
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24892474
• NACRES: NA.32

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 100
• Ensayo: ≥98% (TLC)
• Formulario: powder
• mp: >270 °C
• solubilidad: H₂O: 100 mg/mL; DMSO: soluble (lit.)(lit.); methanol: soluble (lit.)(lit.)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [K+].CC1(C)N([O])C(c2ccc(cc2)C([O-])=O)=[N+]([O-])C1(C)C
• InChI: 1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
• Clave InChI: VYEUQMVIGXFZQU-UHFFFAOYSA-M

Descripción

Descripción general

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) is mainly considered as a scavenger of nitric oxide (NO).

Aplicación

Carboxy-PTIO potassium salt has been used to check the generation of hydroxyl radicals or nitric in reaction mixtures to examine the generation of nitric oxide in reaction mixture. It has also been added to neurons to analyse its effect on glucose/oxygen/serum deprivation (GOSD) condition(4)

Acciones bioquímicas o fisiológicas

Carboxy-PTIO can make a quick reaction with nitric oxide (NO) to produce nitrogen dioxide (NO₂). It can be used to prevent hypotension and endotoxic shock, stimulated by lipopolysaccharide in- vivo. Carboxy-PTIO can also block in vitro vascular relaxation, stimulated by NO.

Reacts with nitric oxide to form carboxy-PTI derivatives which in turn inhibits nitric oxide synthase.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)