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D3506

Sigma-Aldrich

Sodium diethyldithiocarbamate trihydrate

Sinónimos:

Cupral, Diethyldithiocarbamic acid sodium salt

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About This Item

Fórmula lineal:
(C2H5)2NCSSNa · 3H2O
Número de CAS:
20624-25-3
Peso molecular:
225.31
Beilstein:
3920507
Número CE:
205-710-6
Número MDL:
MFCD00150617
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
57654092
NACRES:
NA.77

densidad de vapor

5.9 (vs air)

Nivel de calidad

200

Análisis

≥97% (perchloric acid titration)

formulario

powder or crystals

mp

95-98.5 °C (lit.)

solubilidad

water: 1 g/10 mL, slightly hazy

temp. de almacenamiento

room temp

cadena SMILES

[H]O[H].[H]O[H].[H]O[H].CCN(CC)C(=S)S[Na]

InChI

1S/C5H11NS2.Na.3H2O/c1-3-6(4-2)5(7)8;;;;/h3-4H2,1-2H3,(H,7,8);;3*1H2/q;+1;;;/p-1

Clave InChI

WWGXHTXOZKVJDN-UHFFFAOYSA-M

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Aplicación

Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO2 has been reported. A copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes.

Acciones bioquímicas o fisiológicas

Inhibits induction of macrophage nitric oxide synthase.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Precaución

May form insoluble oxidation products in storage. Sensitivity in colorimetric copper determination not usually affected.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palabra de señalización

Danger

Frases de peligro

H302,H315,H318

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

71513

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Sigma-Aldrich

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P E James et al.
Advances in experimental medicine and biology, 454, 181-187 (1999-01-16)
Although nitric oxide (NO) is a central mediator during endotoxin-induced sepsis, direct detection of tissue NO in vivo, has until recently been difficult, and techniques have relied on indirect measurement of bi-products in blood or invasive technology. We have utilized
Y Suzuki et al.
Free radical research, 28(3), 293-299 (1998-08-04)
To detect nitric oxide (NO) in the rat brain during lipopolysaccharide (LPS)-induced sepsis, electron paramagnetic resonance (EPR) was employed with the NO trapping technique, using an iron and N,N-diethyldithiocarbamate (DETC) complex. An X-band (about 9.5 GHz) EPR system detected a
Tianhui Liu et al.
British journal of pharmacology, 175(24), 4480-4495 (2018-09-29)
Diethyldithiocarbamate (DDC) is a major metabolite of disulfiram that is a potential drug for alcoholism treatment. In the present study, we attempted to explore the possible effect of DDC on non-alcoholic fatty liver disease (NAFLD) and related fibrosis in vivo.
Ji Youn Youn et al.
Redox biology, 46, 102099-102099 (2021-09-13)
The outbreak of COVID-19 has remained uncontained with urgent need for robust therapeutics. We have previously reported sex difference of COVID-19 for the first time indicating male predisposition. Males are more susceptible than females, and more often to develop into
Jonathan H Pérez et al.
The Journal of experimental biology, 223(Pt 1) (2019-12-05)
The hypothalamic-pituitary-adrenal (HPA) axis is under complex regulatory control at multiple levels. Enzymatic regulation plays an important role in both circulating levels of glucocorticoids and target tissue exposure. Three key enzyme pathways are responsible for the immediate control of glucocorticoids.
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