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B1758

Sigma-Aldrich

Biocytin hydrochloride

≥98% (TLC), suitable for drug transporter assays

Sinónimos:

Nε-Biotinyl-L-lysine

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About This Item

Fórmula empírica (notación de Hill):
C16H28N4O4S · xHCl
Número de CAS:
98930-70-2
Peso molecular:
372.48 (free base basis)
Número MDL:
MFCD00136057
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
24891609
NACRES:
NA.26

product name

Biocytin hydrochloride, ≥98% (TLC)

Análisis

≥98% (TLC)

formulario

powder

técnicas

drug transporter assay: suitable

color

white to off-white

temp. de almacenamiento

−20°C

cadena SMILES

Cl.NC(CCCCNC(=O)CCCCC1SCC2NC(=O)NC12)C(O)=O

InChI

1S/C16H28N4O4S.ClH/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14;/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24);1H

Clave InChI

FMGQMNFQNPUYBS-UHFFFAOYSA-N

Categorías relacionadas

Aplicación


  • Biotinylated dextran amine and biocytin hydrochloride are useful tracers for the study of retinal projections in the frog.: This paper highlights the application of biocytin hydrochloride in tracing retinal projections in amphibians. The study demonstrates the efficacy of biocytin hydrochloride in neuroanatomical mapping, facilitating research in visual system development and function (Scalia et al., 1997).


Acciones bioquímicas o fisiológicas

Biocytin is used as a substrate to study the specificity and kinetics of biotinidase(s), to measure biotinidase deficiency and as a model compound to study various uptake mechanisms of cells and tissues.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Barry Wolf et al.
Molecular genetics and metabolism, 86(1-2), 44-50 (2005-09-10)
Biotinidases from various species ranging from fungi and insects to human have specific amino acids, and regions that are evolutionarily conserved. These specific amino acids and regions are further supported by their homology to a variety of amidases and nitrilases
Alessandro R Galloni et al.
eLife, 9 (2020-05-29)
Anatomical similarity across the neocortex has led to the common assumption that the circuitry is modular and performs stereotyped computations. Layer 5 pyramidal neurons (L5PNs) in particular are thought to be central to cortical computation because of their extensive arborisation
Barbara Baur et al.
Brain research, 925(2), 111-121 (2002-01-17)
Uptake of biocytin and biotin was investigated in cultured transformed variants of neuronal (NB2a neuroblastoma) and glial (C6 astrocytoma) CNS cells. NB2a cells took up both compounds but biocytin was transported more efficiently than biotin in the nanomolar concentration range.
Aysun Pabuçcuoğlu et al.
Journal of pediatric gastroenterology and nutrition, 34(1), 59-62 (2001-12-26)
Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased
Ahmaed Baashar et al.
The Journal of comparative neurology, 527(14), 2273-2290 (2019-03-13)
Descending auditory pathways can modify afferent auditory input en route to cortex. One component of these pathways is the olivocochlear system which originates in brainstem and terminates in cochlea. Medial olivocochlear (MOC) neurons also project collaterals to cochlear nucleus and
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