AC-0363

SPINK1 (TATI, PSTI) (EP401) Rabbit Monoclonal Primary Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• forma del anticuerpo: Ig fraction of antiserum
• clon: monoclonal
• descripción: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Formulario: buffered aqueous solution
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: cytoplasmic

Descripción

Descripción general

Serine protease inhibitor Kazal-type 1 (SPINK1), also known as tumor-associated trypsin inhibitor (TATI) and pancreatic secretory trypsin inhibitor (PSTI) is a cytosolic trypsin inhibitor secreted by pancreatic acinar cells and foveolar cells of the stomach that protects the gastrointestinal system from premature trypsinogen auto-digestion. Mutations in SPINK1 are associated with hereditary pancreatitis. Recently, SPINK1 demonstrated utility in differentiating hepatocellular carcinoma (HCC) from precancerous lesions. SPINK1 is detected in all hereditary haemochromatosis HCC and most (79%) of HCC cases, but limited to the luminal surface of large bile ducts in normal liver. SPINK1 expression is also detected in neoplasms of the ovary, bladder, kidney, pancreas, colon, lung, and breast. High expression of SPINK1 is often associated with advanced tumor staging, making it a useful prognostic marker.

Calidad

IVD

IVD

IVD

RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide

Otras notas

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

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Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable