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Merck
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ABK0008

Sigma-Aldrich

InnoBridge ELISA Kit

Sinónimos:

ELISA kit

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About This Item

Código UNSPSC:
41116158
NACRES:
NA.32

forma del anticuerpo

IgG fraction of antiserum

reactividad de especies

human (Human IgG)

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Descripción general

A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full length protein sequence of seven commercial monoclonal antibody biologic drugs (Biologics). Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for any given monoclonal antibody. Once that ‘fingerprint′ is established, then any changes that occur in that mAb during purification or other manipulations will likely expose a new antigenic site which can be detected by the antibodies on the plate.

Aplicación

For research use only. Not for use in diagnostic procedures.

Pictogramas

Corrosion
GHS05

Palabra de señalización

Warning

Frases de peligro

H290,H315,H319

Clasificaciones de peligro

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

Código de clase de almacenamiento

8A - Combustible corrosive hazardous materials

Clase de riesgo para el agua (WGK)

WGK 1

Listados normativos

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EU REACH Annex XVII (Restriction List)

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Certificados de análisis (COA)

Lot/Batch Number

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Xing Wang et al.
Frontiers in pharmacology, 4, 103-103 (2013-08-24)
Antibody arrays were developed to probe a monoclonal antibody's three-dimensional structure (3-D structure). Peptides with overlapping regions were designed to cover the whole mAb light chain and heavy chain, respectively, and used to generate polyclonal antibodies after the conjugation of
Yuanli Song et al.
mAbs, 10(3), 397-405 (2018-01-10)
The elucidation of antibody higher order structure (HOS) is critical in therapeutic antibody development. Since HOS determines the protein bioactivity and chemo-physical properties, this knowledge can help to ensure that the safety and efficacy attributes are not compromised. Protein conformational
Biosimilar mAb in-process Sample Higher Order Structure Analysis with Protein Conformational Array ELISA.
Michael Davies, Gan Wang, Jian Gong, Guofeng Fu and Xing Wang
Pharmaceut. Res., 1-11 (2016)
Soon Kwan Jung et al.
mAbs, 6(5), 1163-1177 (2014-12-18)
Remsima (infliximab) was recently approved as the world's first biosimilar monoclonal antibody (mAb) in both the European Union and Korea. To achieve this, extensive physicochemical characterization of Remsima in relation to Remicade was conducted in order to demonstrate the highly

Artículos

Protein Conformation Array Multiplexing

Monoclonal antibodies (mAbs) are the fastest growing class of human therapeutics within the field of biologics, having predicted worldwide sales of $125 billion by 2020 based on current approval rates.

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