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A5835

Sigma-Aldrich

γ-Aminobutyric acid

≥99%, suitable for ligand binding assays, BioXtra

Sinónimos:

3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid

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About This Item

Fórmula lineal:
NH2(CH2)3COOH
Número de CAS:
56-12-2
Peso molecular:
103.12
Beilstein:
906818
Número CE:
200-258-6
Número MDL:
MFCD00008226
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
24891025
NACRES:
NA.26

Nombre del producto

γ-Aminobutyric acid, BioXtra, ≥99%

Línea del producto

BioXtra

Nivel de calidad

200

Ensayo

≥99%

Formulario

powder

técnicas

ligand binding assay: suitable

impurezas

<0.0005% Phosphorus (P)
<0.1% Insoluble matter

residuo de ign.

<0.1%

color

white

mp

195 °C (dec.) (lit.)

solubilidad

H2O: 0.5 M at 20 °C, clear, colorless

trazas de anión

chloride (Cl-): <0.04%
sulfate (SO42-): <0.05%

trazas de catión

Al: <5 mg/kg
Ca: <20 mg/kg
Cu: <5 mg/kg
Fe: <5 mg/kg
K: <50 mg/kg
Mg: <50 mg/kg
NH4+: <500 mg/kg
Na: <70 mg/kg
Pb: <10 mg/kg
Zn: <5 mg/kg

cadena SMILES

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

Clave InChI

BTCSSZJGUNDROE-UHFFFAOYSA-N

Información sobre el gen

human ... SLC6A1(6529) , SLC6A11(6538) , SLC6A12(6539)
rat ... Gabra1(29705) , Gabra2(29706) , Olr1750(294204) , Slc6a1(79212) , Slc6a12(50676)

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Descripción general

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.

Aplicación

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.

Acciones bioquímicas o fisiológicas

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.
Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl− conductance.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCD3795
BCBT6042
BCBZ1867
BCBT8658
BCBR3355V

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Piril Hepsomali et al.
Frontiers in neuroscience, 14, 923-923 (2020-10-13)
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role
Li-Jie Wang et al.
Experimental and therapeutic medicine, 14(2), 1373-1380 (2017-08-16)
Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess
Weiqiao Zhao et al.
Nature communications, 10(1), 124-124 (2019-01-12)
Innate preference toward environmental conditions is crucial for animal survival. Although much is known about the neural processing of sensory information, how the aversive or attractive sensory stimulus is transformed through central brain neurons into avoidance or approaching behavior is
Claudio Giachino et al.
Development (Cambridge, England), 141(1), 83-90 (2013-11-29)
Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express
Vincent Paille et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(22), 9353-9363 (2013-05-31)
The spike-timing-dependent plasticity (STDP), a synaptic learning rule for encoding learning and memory, relies on relative timing of neuronal activity on either side of the synapse. GABAergic signaling has been shown to control neuronal excitability and consequently the spike timing
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