Saltar al contenido
Merck

A0420

Sigma-Aldrich

Anti-Human IgM (μ-chain specific)−Peroxidase antibody produced in goat

affinity isolated antibody

Sinónimos:

Goat Anti-Human IgM (μ-chain specific)−HRP

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.46

En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

goat

Nivel de calidad

conjugado

peroxidase conjugate

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

secondary antibodies

clon

polyclonal

reactividad de especies

human

técnicas

direct ELISA: 1:50,000
dot blot: 1:100,000 (chemiluminescent)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

¿Está buscando productos similares? Visita Guía de comparación de productos

Descripción general

B cells predominantly secrete IgM antibodies as pentamers, but may also secrete them as hexamers which are capable of activating the complement cascade more efficiently.
Goat anti-human IgM (mu-chain specific)-peroxidase antibody is specific for human IgM and does not bind to other human Igs. Furthermore, the antibody does not react with mouse and rat IgG. Hence, the antibody conjugate yields reduced background with mouse or rat samples.

Inmunógeno

human IgM

Aplicación

Anti- Human IgM was used in an ELISA assay to determine the concentration of IgM secreted by CH12 B lymphoma cells stimulated by LPS.
Goat anti-human IgM (mu-chain specific)-peroxidase antibody can be used:
  • for dot blot (1:100,000) and immunohistochemistry (1:200 using formalin-fixed, paraffin-embedded sections) applications.
  • in immunoblotting
  • sandwich immunoassay

Acciones bioquímicas o fisiológicas

IgM plays a key role in engulfing of the apoptotic cells. A reduction in serum IgM levels leads to increased autoimmune response and higher risk for infections. IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating clearance of tissue based molecules.

Forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 0.05% MIT

Nota de preparación

Prepared by the two-step glutaraldehyde method described by Avrameas, S., et al., Scand. J. Immunol., 8, Suppl. 7, 7 (1978).

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

¿No encuentra el producto adecuado?  

Pruebe nuestro Herramienta de selección de productos.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Skin Sens. 1

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves


  • Elija entre una de las versiones más recientes:

    Certificados de análisis (COA)

    Lot/Batch Number

    ¿No ve la versión correcta?

    Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

    ¿Ya tiene este producto?

    Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

    Visite la Librería de documentos

    Kioa L Wijnsma et al.
    Pediatric nephrology (Berlin, Germany), 31(11), 2163-2170 (2016-06-01)
    In the majority of pediatric patients, the hemolytic-uremic syndrome (HUS) is caused by an infection with Shiga toxin-producing Escherichia coli (STEC), mostly serotype O157. It is important to discriminate between HUS caused by STEC and complement-mediated HUS (atypical HUS) due
    FulmFulminant Amoebic Colitis: Role of the Innate and Adaptive Immune Responses (2012)
    Cancer marker detection in human serum with a point-of-care low-cost system
    Grosso P, et al.
    Sensors and Actuators B, Chemical, 147(2), 475-480 (2010)
    Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers
    Garambois V, et al.
    BMC Cancer, 4(1), 75-75 (2004)
    Edgar A Melgoza-González et al.
    Transboundary and emerging diseases, 69(4), e734-e745 (2021-10-17)
    The SARS-CoV-2 virus was detected for the first time in December 2019 in Wuhan, China. Currently, this virus has spread around the world, and new variants have emerged. This new pandemic virus provoked the rapid development of diagnostic tools, therapies

    Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

    Póngase en contacto con el Servicio técnico