95200

Vitamin B_12a hydrochloride

≥96% (UV), ≥96% (HPLC)

• Sinónimos: Hydroxocobalamin hydrochloride
• Fórmula empírica (notación de Hill): C₆₂H₈₉CoN₁₃O₁₅P · HCl
• Número de CAS: 59461-30-2
• Peso molecular: 1382.82
• Número CE: 261-772-4
• Número MDL: MFCD00167463
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 57653658
• NACRES: NA.79

Propiedades

• origen biológico: fermentation/recombinant
• Análisis: ≥96% (HPLC); ≥96% (UV)
• formulario: powder or crystals
• pérdida: ≤12% loss on drying, 20 °C (HV)
• color: red to dark red
• solubilidad: methanol: 10 mg/mL at 20 °C, clear, dark red
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N([Co+]O)C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78
• InChI: 1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H;;1H2/q;;+3;/p-3/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;;/m1.../s1
• Clave InChI: KEHNCSYXYMMUCO-BXSGNKEGSA-K

Descripción

Aplicación

Vitamin B12a hydrochloride has been used as an antidote for cyanide poisoning.

Acciones bioquímicas o fisiológicas

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

Otras notas

Review

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)