43107

Vitamina B₁₂

tested according to Ph. Eur.

• Sinónimos: α-(5,6-Dimetilbencimidazolil)cianocobamida, CN-Cbl, Cianocob(III)alamina, Cianocobalamina
• Fórmula empírica (notación de Hill): C₆₃H₈₈CoN₁₄O₁₄P
• Número de CAS: 68-19-9
• Peso molecular: 1355.37
• Beilstein: 4122889
• Número CE: 200-680-0
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 329756307
• NACRES: NA.21

Propiedades

• origen biológico: fermentation/recombinant
• Nivel de calidad: 100
• Agency: USP/NF; tested according to Ph. Eur.
• Análisis: 96.0-102.0% dry basis
• formulario: powder
• color: dark red
• solubilidad: water: soluble 1 gm in 80 ml; acetone: insoluble; alcohol: soluble; chloroform: insoluble; diethyl ether: insoluble
• aplicaciones: cell analysis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@
• InChI: 1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1
• Clave InChI: RMRCNWBMXRMIRW-QJRSUKKJSA-L

Descripción

Descripción general

Cyanocobalamin, also referred to as Vitamin B₁₂, is a water soluble vitamin.

Aplicación

Cyanocobalamin was added in the assay buffer during the analysis step of ELISA for ensuring that all transcobalamin was saturated with cobalamin before analysis. Cyanocobalamin was also used for examining its impact on the expression of mPer1 and mPer2 in vivo.

Acciones bioquímicas o fisiológicas

Cyanocobalamin plays a role in functioning of brain and nervous system. It is also involved in hematopoiesis. Vitamin B₁₂ deficiency leads to megaloblastic anemia. It is also associated with irreversible nervous system breakdown leading to spinal cord degeneration.

Cyanocobalamin refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. Cyanocobalamin along with other B vitamins thiamine (B1) and pyridoxine (B6) blocks the thermal hyperalgesia in rats with neuropathic pain caused by spinal ganglia compression (CCD) or loose ligation of the sciatic nerve (CCI). It can stimulate the anaerobic biodegradation of chloroform.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)