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Merck
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475R-9

Sigma-Aldrich

INSM1 (MRQ-70) Rabbit Monoclonal Antibody

Sinónimos:

Insulinoma-associated protein 1

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About This Item

Código UNSPSC:
12352203
clon:
MRQ-70, monoclonal
application:
IHC (p)
reactividad de especies:
human
técnicas:
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
citations:
6

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

MRQ-70, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (475R-94)
vial of 0.1 mL concentrate Research Use Only (475R-94-RUO)
vial of 0.5 mL concentrate (475R-95)
vial of 1.0 mL concentrate (475R-96)
vial of 1.0 mL concentrate Research Use Only (475R-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (475R-97)
vial of 7.0 mL pre-dilute ready-to-use (475R-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)

fabricante / nombre comercial

Cell Marque™

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotipo

IgG

control

pancreas

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

nuclear

Categorías relacionadas

Descripción general

Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor1. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression5-6.

Calidad

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Sanjay Mukhopadhyay et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(1), 100-109 (2018-08-30)
Recent evidence suggests a role for the nuclear marker INSM1 in the diagnosis of neuroendocrine lung neoplasms. The aim of this study was to determine the utility of INSM1 as a marker of neuroendocrine differentiation using a large series of
Lilla M Farkas et al.
Neuron, 60(1), 40-55 (2008-10-23)
Basal (intermediate) progenitors are the major source of neurons in the mammalian neocortex. The molecular machinery governing basal progenitor biogenesis is unknown. Here, we show that the zinc-finger transcription factor Insm1 (insulinoma-associated 1) is expressed specifically in progenitors undergoing neurogenic
Mathias S Gierl et al.
Genes & development, 20(17), 2465-2478 (2006-09-05)
The pancreatic and intestinal primordia contain epithelial progenitor cells that generate many cell types. During development, specific programs of gene expression restrict the developmental potential of such progenitors and promote their differentiation. The Insm1 (insulinoma-associated 1, IA-1) gene encodes a
Jason N Rosenbaum et al.
Neural development, 6, 6-6 (2011-02-03)
Insm1 is a zinc-finger transcription factor transiently expressed throughout the developing nervous system in late progenitors and nascent neurons. Insm1 is also highly expressed in medulloblastomas and other neuroendocrine tumors. We generated mice lacking the Insm1 gene and used them
Michael S Lan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(7), 2024-2033 (2009-02-28)
Zinc-finger transcription factors are DNA-binding proteins that are implicated in many diverse biological functions. INSM1 (formerly IA-1) contains five zinc-finger motifs and functions as a transcription factor. INSM1 protein structure is highly conserved in homologues of different species. It is

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