43420

β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate

≥95.0% (HPLC)

• Sinónimos: β-DPNH, β-NADH, DPNH, Diphosphopyridine nucleotide, reduced form, NADH
• Fórmula empírica (notación de Hill): C₂₁H₂₇N₇Na₂O₁₄P₂ · xH₂O
• Número de CAS: 606-68-8
• Peso molecular: 709.40 (anhydrous basis)
• Número CE: 210-123-3
• Número MDL: MFCD03791273
• Código UNSPSC: 41106305
• ID de la sustancia en PubChem: 329756341
• NACRES: NA.51

Propiedades

• Análisis: ≥95.0% (HPLC)
• formulario: powder
• trazas de catión: Ca: ≤200 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤20 mg/kg; Fe: ≤5 mg/kg; K: ≤200 mg/kg; Mg: ≤200 mg/kg; Mn: ≤5 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• cociente de absorbancia: A_{260/340 nm} ≤2.40
• temp. de almacenamiento: −20°C
• cadena SMILES: O.[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
• InChI: 1S/C21H29N7O14P2.2Na.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;;1H2/q;2*+1;/p-2/t10-,11-,13-,14-,15-,16-,20-,21-;;;/m1.../s1
• Clave InChI: FWBNCIFELNNJCX-UHOVGGJYSA-L

Descripción

Aplicación

As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Nicotinamide adenine dinucleotide (NAD) and NADH form a redox pair. NAD/NADH is a coenzyme that supports redox reactions via the transport of electrons in a vast array of applications. NAD is also involved in post-translational (Poly(ADP-ribose) polymerization) modifications of proteins.

Acciones bioquímicas o fisiológicas

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD⁺/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

Envase

Packaged by solid weight.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)