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Certificado de origen (COO)/COA

352M-9

Napsin A (MRQ-60) Mouse Monoclonal Antibody

Name: Napsin A (MRQ-60) Mouse Monoclonal Antibody
Brand: SIGMA

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

MRQ-60, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (352M-94)
vial of 0.5 mL concentrate (352M-95)
bottle of 1.0 mL predilute (352M-97)
vial of 1.0 mL concentrate (352M-96)
bottle of 7.0 mL predilute (352M-98)

fabricante / nombre comercial

Cell Marque^™

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotipo

IgG1κ

control

lung adenocarcinoma, renal cell carcinoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic

Información sobre el gen

human ... NAPSA(9476)

Descripción general

Napsin is a pepsin-like aspartic proteinase in the A1 clan of the AA clade ofproteinases. Napsin A is involved in processing propeptide pulmonary surfactant protein B(proSP-B) in the lung. In normal, benign tissue, Napsin A has expressed in type II pneumocytesof the lung and proximal tubules of the kidney. Napsin A is a useful marker for lungadenocarcinoma.

Calidad

IVD

RUO

Ligadura / enlace

Napsin A Positive Control Slides, Product No. 352S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung.

Frank Brasch et al.

The Journal of biological chemistry, 278(49), 49006-49014 (2003-09-18)

Surfactant protein B (SP-B) is a critical component of pulmonary surfactant, and a deficiency of active SP-B results in fatal respiratory failure. SP-B is synthesized by type-II pneumocytes as a 42-kDa propeptide (proSP-B), which is posttranslationally processed to an 8-kDa

Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung.

Jaishree Jagirdar

Archives of pathology & laboratory medicine, 132(3), 384-396 (2008-03-06)

Immunohistochemistry is a very valuable and often used tool in the differential diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful application is in distinguishing primary lung tumors from metastatic tumors to the lung from

Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma.

Justin A Bishop et al.

Human pathology, 41(1), 20-25 (2009-09-11)

Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non-small cell carcinomas. Immunohistochemistry for thyroid transcription factor-1 is widely used in the diagnosis of pulmonary adenocarcinomas because it marks approximately 75% of lung

Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung.

Jiqing Ye et al.

Applied immunohistochemistry & molecular morphology : AIMM, 19(4), 313-317 (2011-04-06)

Differentiation of primary from metastatic adenocarcinoma in the lung can be challenging, and it demands sensitive and specific biomarkers, especially when the tissue for diagnosis is limited. Thyroid transcription factor-1 (TTF-1) has been considered a reliable marker for adenocarcinoma of

Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions.

Annika Dejmek et al.

Diagnostic cytopathology, 35(8), 493-497 (2007-07-20)

The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on formalin-fixed paraffin embedded

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