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Merck
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Key Documents

320M-1

Sigma-Aldrich

Cytokeratin 20 (Ks20.8) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

Ks20.8, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (320M-14)
vial of 0.5 mL concentrate (320M-15)
bottle of 1.0 mL predilute (320M-17)
vial of 1.0 mL concentrate (320M-16)
bottle of 7.0 mL predilute (320M-18)

fabricante / nombre comercial

Cell Marque™

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:500

isotipo

IgG2aκ

control

colon carcinoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic

Información sobre el gen

human ... KRT20(54474)

Descripción general

Cytokeratin 20 is a 46-kDa intermediate filament protein that reacts primarily with gastricand intestinal epithelium, urothelium, and Merkel cells. Anti-Cytokeratin 20 is usefulin the identification of specific types of these epithelial cells under normal, hyperplastic,and neoplastic conditions. Cytokeratin 20 has been detected in various adenocarcinomas,including those of the colon and stomach. Merkel cell carcinomas have shown reactivity. Incontrast, carcinomas of the breast are generally non-reactive.

Calidad


IVD
IVD
IVD
RUO

Ligadura / enlace

Cytokeratin 20 Positive Control Slides , Product No. 320S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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A Rullier et al.
The American journal of surgical pathology, 24(6), 870-876 (2000-06-08)
In the liver, the immunostaining of cytokeratins (CK) 7 and 20 has been used to distinguish usual peripheral cholangiocarcinomas (CC) and colorectal carcinoma metastasis (CRM). However, other subtypes of CC are not infrequent and may be particularly difficult to distinguish
T Tot
Cancer, 85(1), 171-177 (1999-01-28)
Metastatic adenocarcinoma in the liver with an unidentified primary tumor site is a common clinical problem. Pathologists often are asked to identify the primary tumor site. The histologic picture itself usually is not helpful, because the histology may be similar
T Tot
Cancer, 92(10), 2727-2732 (2001-12-18)
Immunohistochemistry is a useful method in the differential diagnosis between pleural mesotheliomas and metastatic adenocarcinomas to the pleura. Cytokeratin (CK) 5-6 is one of the most specific mesothelioma-associated antibodies. Cytokeratin 20 and CK7 have been used successfully in studies determining
Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas
Wang NP, Zee S, Zarbo RJ, Bacchi CE, Gown AM
Appl. Immunohistochem., 3, 99-107 (1995)
Sean K Lau et al.
Human pathology, 33(12), 1175-1181 (2003-01-07)
Distinguishing hepatocellular carcinoma (HCC) from cholangiocarcinoma (CC) and metastatic adenocarcinoma (MA) involving the liver can be problematic, often requiring the use of immunohistochemistry to facilitate diagnosis. Hep Par 1, a monoclonal antibody with expression confined primarily to benign and malignant
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