282200

Galangin

autophagy inducing flavonoid

• Sinónimos: 3,5,7-Trihydroxyflavone, Norizalpinin
• Fórmula empírica (notación de Hill): C₁₅H₁₀O₅
• Número de CAS: 548-83-4
• Peso molecular: 270.24
• Beilstein: 272179
• Número CE: 208-960-4
• Número MDL: MFCD00006833
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 57648294
• NACRES: NA.79

Propiedades

• Ensayo: ≥95% (HPLC)
• Formulario: powder
• color: yellow
• mp: 214-215 °C (lit.)
• cadena SMILES: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
• Clave InChI: VCCRNZQBSJXYJD-UHFFFAOYSA-N
• Información sobre el gen: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

Descripción

Descripción general

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

Aplicación

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Acciones bioquímicas o fisiológicas

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves