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Merck
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Key Documents

248M-1

Sigma-Aldrich

Ep-CAM/Epithelial Specific Antigen (MOC-31) Mouse Monoclonal Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

MOC-31, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (248M-14)
vial of 0.5 mL concentrate (248M-15)
bottle of 1.0 mL predilute (248M-17)
vial of 1.0 mL concentrate (248M-16)
bottle of 7.0 mL predilute (248M-18)

fabricante / nombre comercial

Cell Marque™

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotipo

IgG1κ

control

colon carcinoma

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic

Información sobre el gen

human ... EPCAM(4072)

Descripción general

Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on the membrane of cells in most epithelial tissues. Immunoreactivity with the antibody to Ep-CAM has been seen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show Ep-CAM expression. Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes. In conjunction with other markers, Ep-CAM can be used as an aid in determining neoplasms of epithelial origin, such as distinguishing between lung adenocarcinoma and mesothelioma.

Calidad


IVD
IVD
IVD
RUO

Ligadura / enlace

Ep-CAM Positive Control Slides, Product No. 248S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Información legal

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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James S Lewis et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 18(11), 1471-1481 (2005-06-25)
Sarcomatoid carcinomas are rare malignancies which represent poorly differentiated epithelial tumors that may be difficult to recognize as such. While some cases may have obvious epithelial areas, the sarcomatoid areas are poorly distinguishable from true sarcoma at the light microscopic
Murat Gokden et al.
Diagnostic cytopathology, 33(3), 166-172 (2005-08-04)
Differential diagnosis of primary and metastatic carcinomas of the liver can be problematic and may require immunohistochemical work-up. Recently, new immunohistochemical markers have been introduced with promising results in this area. We studied three of these markers, human hepatocyte antibody
Sanjay Kakar et al.
Archives of pathology & laboratory medicine, 131(11), 1648-1654 (2007-11-06)
Immunohistochemistry plays a crucial role in the diagnosis of hepatocellular carcinoma and in its distinction from other primary and metastatic neoplasms. Because limited tissue is available with fine-needle and core biopsies, appropriate selection of antibodies is imperative. To review the
Jonathan L Hecht et al.
Cancer, 108(1), 56-59 (2005-12-06)
It has been shown previously that detection of the epithelial membrane antigen using the mouse monoclonal antibody MOC-31 has diagnostic utility in the distinction between mesothelioma and metastatic carcinoma in body fluids. The current immunohistochemical study confirmed the effectiveness of
J E King et al.
Histopathology, 48(3), 223-232 (2006-01-25)
Immunohistochemistry is frequently employed to aid the distinction between mesothelioma and pulmonary adenocarcinoma metastatic to the pleura, but there is uncertainty as to which antibodies are most useful. We analysed published data in order to establish sensitivity and specificity of
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