16758

Poli(etilenglicol)-bloque-poli(propilenglicol)-bloque-poli(etilenglicol))

purified, non-ionic

• Sinónimos: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
• Número de CAS: 9003-11-6
• Número MDL: MFCD00082049
• Código UNSPSC: 12352104
• NACRES: NA.25

Propiedades

• Nivel de calidad: 100
• formulario: powder
• calidad: purified
• impurezas: ≤1.0% water
• pH: 5.0-7.5
• solubilidad: soluble, clear, colorless
• trazas de catión: Al: ≤5 mg/kg; As: ≤0.05 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤1000 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• Absorción UV: λ: 260 nm A_max: ≤0.3; λ: 280 nm A_max: ≤0..2
• idoneidad: no residue for filter test
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• Clave InChI: RVGRUAULSDPKGF-UHFFFAOYSA-N

Descripción

Descripción general

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Aplicación

Poloxamer 407 has been used:

• as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
• for VLDL secretion assay in mice
• to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Acciones bioquímicas o fisiológicas

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)