Y0001599

Wedelolactone

European Pharmacopoeia (EP) Reference Standard

• Sinónimos: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 7-Methoxy-5,11,12-trihydroxycoumestan
• Fórmula empírica (notación de Hill): C₁₆H₁₀O₇
• Número de CAS: 524-12-9
• Peso molecular: 314.25
• Número MDL: MFCD07778564
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329831504
• NACRES: NA.24

Propiedades

• grado: pharmaceutical primary standard
• familia API: wedelolactone
• fabricante / nombre comercial: EDQM
• aplicaciones: pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: −20°C
• cadena SMILES: COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
• InChI: 1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
• Clave InChI: XQDCKJKKMFWXGB-UHFFFAOYSA-N

Descripción

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Wedelolactone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC₅₀ < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Consejos de prudencia: P264 - P270 - P301 + P312 - P501
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1