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R0145000

Ramipril

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

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About This Item

Fórmula empírica (notación de Hill):
C23H32N2O5
Número de CAS:
87333-19-5
Peso molecular:
416.51
Número MDL:
MFCD00865775
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329823973
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

ramipril

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3

InChI

1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1

Clave InChI

HDACQVRGBOVJII-JBDAPHQKSA-N

Información sobre el gen

human ... ACE(1636)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Ramipril EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Angiotensin converting enzyme (ACE) inhibitor.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Producto relacionado

Referencia del producto
Descripción
Precios

1598303

Ramipril, United States Pharmacopeia (USP) Reference Standard

1598314

Ramipril Related Compound A, United States Pharmacopeia (USP) Reference Standard

1598347

Ramipril Related Compound D, United States Pharmacopeia (USP) Reference Standard

R0145005

Ramipril impurity A, European Pharmacopoeia (EP) Reference Standard

R0145020

Ramipril impurity D, European Pharmacopoeia (EP) Reference Standard

R0145010

Ramipril impurity B, European Pharmacopoeia (EP) Reference Standard

R0145015

Ramipril impurity C, European Pharmacopoeia (EP) Reference Standard

1598323

Ramipril Related Compound B, United States Pharmacopeia (USP) Reference Standard

1598338

Ramipril Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP751

Ramipril, British Pharmacopoeia (BP) Reference Standard

BP754

Ramipril impurity K, British Pharmacopoeia (BP) Reference Standard

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H360FD

Clasificaciones de peligro

Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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J E Frampton et al.
Drugs, 49(3), 440-466 (1995-03-01)
Ramipril is a second generation angiotensin converting enzyme (ACE) inhibitor. Like enalapril, it is a prodrug and is hydrolysed in vivo to release the active metabolite, ramiprilat, which has a long elimination half-life, permitting once-daily administration. The antihypertensive efficacy of
S Meisel et al.
Clinical pharmacokinetics, 26(1), 7-15 (1994-01-01)
Ramipril is a long-acting nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor introduced for clinical use about a decade ago. Ramipril is a prodrug that undergoes de-esterification in the liver to form ramiprilat, its active metabolite. Ramipril rapidly distributes to all tissues
Thomas Unger
The American journal of cardiology, 91(10A), 28G-34G (2003-06-05)
The renin-angiotensin system evolved to maintain volume homeostasis and blood pressure and to prevent ischemia during acute volume loss. But in the present age, these mechanisms are redundant, and the clinical significance of angiotensin II results from its pathologic effects
J F Burris
Clinical therapeutics, 15(3), 476-485 (1993-05-01)
Ambulatory blood pressure monitoring (ABPM) has been available since the mid-1970s. Widespread use of ABPM in research settings has led to an appreciation of its advantages and disadvantages. ABPM is a valuable research tool because of its ability to evaluate
Carolina De Ciuceis et al.
Hypertension (Dallas, Tex. : 1979), 64(4), 717-724 (2014-07-02)
Structural alterations of subcutaneous small-resistance arteries are associated with a worse clinical prognosis in hypertension and non-insulin-dependent diabetes mellitus. The effects of the direct renin inhibitor aliskiren on microvascular structure were never previously evaluated. Therefore, we investigated the effects of
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