PHR1782

Sulfato de hidroxicloroquina

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Sulfato de 7-cloro-4-[4-(N-etil-N-b-hidroxietilamino)-1-metilbutilamino]quinolina
• Fórmula empírica (notación de Hill): C₁₈H₂₆ClN₃O · H₂SO₄
• Número de CAS: 747-36-4
• Peso molecular: 433.95
• Número CE: 212-019-3
• Número MDL: MFCD00078203
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823611
• NACRES: NA.24

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 300
• grado: certified reference material; pharmaceutical secondary standard
• Agency: BP; EP; USP; traceable to BP 1100; traceable to USP 1327000
• familia API: hydroxychloroquine
• formulario: powder or crystals
• CofA: current certificate can be downloaded
• envase: pkg of 1 g
• condiciones de almacenamiento: protect from light
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• color: white to off-white
• pH: 3.5-5.5 (1% in aqueous solution, pH <6.0)
• mp: 238-241 °C
• solubilidad: chloroform: practically insoluble; ethanol: practically insoluble; ether: practically insoluble; water: soluble
• aplicaciones: pharmaceutical (small molecule)
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-30°C
• cadena SMILES: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• Clave InChI: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Información sobre el gen: human ... TLR7(51284) , TLR9(54106)

Descripción

Descripción general

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Hydroxychloroquine Sulfate can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

El sulfato de hidroxicloroquina es un antiinflamatorio (vía TNF), un antirreumático modificador de la enfermedad (DMARD) y un inhibidor de la hemo polimerasa. Se utiliza para tratar el paludismo.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0287 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302,H315,H319
• Consejos de prudencia: P301 + P312 + P330 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable