PHR1587

Timerosal

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Etilmercuritiosalicilato de sodio, Mercuri-([o-carboxifenil]tio)etil sodium salt, Ácido 2-(etilmercuriomercapto)benzoico sodium salt, Ácido etilmercuritiosalicílico sodium salt
• Fórmula lineal: 2-(C₂H₅HgS)C₆H₄CO₂Na
• Número de CAS: 54-64-8
• Peso molecular: 404.81
• Beilstein: 8169555
• Número CE: 200-210-4
• Número MDL: MFCD00013062
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823493
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to Ph. Eur. Y0000109; traceable to USP 1659000
• familia API: thimerosal
• CofA: current certificate can be downloaded
• envase: pkg of 1 g
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 234-237 °C (dec.) (lit.)
• aplicaciones: pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: [Na+].CC[Hg]Sc1ccccc1C([O-])=O
• InChI: 1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2
• Clave InChI: RTKIYNMVFMVABJ-UHFFFAOYSA-L

Descripción

Descripción general

Thimerosal belongs to the group of alkyl mercury compounds. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Thimerosal may be used as a pharmaceutical reference standard for the quantification of the analyte in ophthalmic solutions using spectrophotometric technique.

Acciones bioquímicas o fisiológicas

El timerosal es un reactivo oxidante de sulfhidrilo (tiol) capaz de inhibir una amplia variedad de enzimas dependientes del sulfhidrilo y proteínas como la metionina sintasa dependiente de PI3-cinasa, receptores de transporte de glutamato y las ATPasas dependientes de Na⁺+K⁺.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA6959 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330,H373,H410
• Consejos de prudencia: P262 - P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Clasificaciones de peligro: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral
• Órganos de actuación: Kidney
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable