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PHR1448

Supelco

Sulfadimethoxine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Sulfadimethoxine, 4-Amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide

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About This Item

Fórmula empírica (notación de Hill):
C12H14N4O4S
Número de CAS:
122-11-2
Peso molecular:
310.33
Beilstein:
306856
Número CE:
204-523-7
Número MDL:
MFCD00057345
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329822608
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

300

Agency

traceable to USP 1626001

familia API

sulfadimethoxine

CofA

current certificate can be downloaded

envase

pkg of 500 mg

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1

InChI

1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

Clave InChI

ZZORFUFYDOWNEF-UHFFFAOYSA-N

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Descripción general

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Sulfadimethoxine is an long acting sulfonamide antibiotic, commonly used against a broad spectrum of bacterial infections in animals. Its mode of action involves the inhibition of folic acid synthesis in prokaryotes. It is also widely used in veterinary medication to treat coccidiosis in cats and dogs.

Aplicación

Sulfadimethoxine may be used as a pharmaceutical reference standard for the quantification of the analyte in veterinary formulations using liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA2825 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Small Animal Clinical Pharmacology (2011)
Simultaneous determination of sulfamethoxypyridazine, sulfamethoxazole, sulfadimethoxine and their associated compounds by liquid chromatography.
Nevado JJ, et al.
Analytica Chimica Acta, 442(2), 241-248 (2001)
Minjoo Kim et al.
PloS one, 10(3), e0119519-e0119519 (2015-03-18)
Existing data on the association between being overweight and cardiovascular morbidity and mortality risk in adults are inconsistent. We prospectively and longitudinally investigated the effects of weight on arterial stiffness and plasma metabolites in middle-aged subjects (aged 40-55 years). A
Zhe Meng et al.
Food chemistry, 174, 597-605 (2014-12-23)
A novel UPLC-MS/MS method for quantification and confirmation of eight fluoroquinolones, five sulphonamides (SAs) and four acetyled metabolites in milk is developed. Their main fragmentation pathways were presented. The limits of quantification were in the range of 0.01-0.29 μg kg(-1)
Werner Siegmund et al.
British journal of clinical pharmacology, 79(3), 501-513 (2014-09-30)
The rare association of flupirtine with liver injury is most likely caused by reactive quinone diimines and their oxidative formation may be influenced by the activities of N-acetyltransferases (NAT) that conjugate the less toxic metabolite D13223, and by glucuronosyltransferases (UGT)
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