PHR1060

Mesalamine

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: 5-Aminosalicylic acid, 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine
• Fórmula lineal: H₂NC₆H₃-2-(OH)CO₂H
• Número de CAS: 89-57-6
• Peso molecular: 153.14
• Beilstein: 2090421
• Número CE: 201-919-1
• Número MDL: MFCD00007877
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823090
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 1075; traceable to Ph. Eur. Y0000297; traceable to USP 1392705
• familia API: mesalamine, mesalazine
• CofA: current certificate can be downloaded
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• mp: 275-280 °C (dec.) (lit.)
• aplicaciones: pharmaceutical (small molecule)
• formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: Nc1ccc(O)c(c1)C(O)=O
• InChI: 1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
• Clave InChI: KBOPZPXVLCULAV-UHFFFAOYSA-N
• Información sobre el gen: human ... ALOX5(240) , PPARG(5468) , PTGS1(5742) , PTGS2(5743)

Descripción

Descripción general

Mesalamine is a drug, which is structurally similar to salicylates. It exhibits anti-inflammatory activity and is widely used as a medication for the treatment of inflammatory bowel disease, including ulcerative proctitis and Crohn′s disease.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Mesalamine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA7173 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H317,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): No data available
• Punto de inflamabilidad (°C): No data available