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P0300000

Paracetamol

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Acetaminophen, 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol

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About This Item

Fórmula lineal:
CH3CONHC6H4OH
Número de CAS:
103-90-2
Peso molecular:
151.16
Beilstein:
2208089
Número CE:
203-157-5
Número MDL:
MFCD00002328
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329820028
NACRES:
NA.24

grado

pharmaceutical primary standard

descripción

API family: acetaminophen

familia API

paracetamol, acetaminophen

fabricante / nombre comercial

EDQM

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

168-172 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

Clave InChI

RZVAJINKPMORJF-UHFFFAOYSA-N

Información sobre el gen

human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Analgesic.
Paracetamol EP reference standard, intended for use only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
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1003010

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PHR1531

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PHR1530

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PHR1612

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1003027

Acetaminophen Related Compound B, United States Pharmacopeia (USP) Reference Standard

1003042

Acetanilida, United States Pharmacopeia (USP) Reference Standard

1003100

Acetaminophen Related Compound J, United States Pharmacopeia (USP) Reference Standard

1003031

Acetaminophen Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR1642

Acetaminophen Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

1003064

4-Nitrophenol, United States Pharmacopeia (USP) Reference Standard

1026004

3-Aminophenol, United States Pharmacopeia (USP) Reference Standard

Y0001781

Paracetamol for equipment qualification, European Pharmacopoeia (EP) Reference Standard

PHR1745

4-Aminophenol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

BP371

Paracetamol, British Pharmacopoeia (BP) Reference Standard

Y0001945

Paracetamol impurity J, European Pharmacopoeia (EP) Reference Standard

Y0001955

4-Aminophenol, European Pharmacopoeia (EP) Reference Standard

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

364.3 °F - Pensky-Martens closed cup

Punto de inflamabilidad (°C)

184.6 °C - Pensky-Martens closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
Edward Munsterhjelm et al.
Anesthesiology, 103(4), 712-717 (2005-09-30)
Acetaminophen (paracetamol) is widely used for postoperative analgesia. Its mechanism of action is inhibition of prostaglandin synthesis in the central nervous system, and acetaminophen is traditionally not considered to influence platelet function. The authors studied the dose-dependent inhibition of platelet
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
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