N5410

Nicotinic acid

meets USP testing specifications

• Sinónimos: 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃
• Fórmula empírica (notación de Hill): C₆H₅NO₂
• Número de CAS: 59-67-6
• Peso molecular: 123.11
• Beilstein: 109591
• Número CE: 200-441-0
• Número MDL: MFCD00006391
• Código UNSPSC: 12352106
• ID de la sustancia en PubChem: 24897734
• NACRES: NA.21

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Agency: USP/NF; meets USP testing specifications
• Análisis: 99.0-101.0% dry basis
• formulario: powder
• color: white
• mp: 236-239 °C (lit.)
• aplicaciones: pharmaceutical (small molecule)
• cadena SMILES: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• Clave InChI: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Información sobre el gen: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Descripción

Descripción general

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

Aplicación

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

Acciones bioquímicas o fisiológicas

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H319
• Consejos de prudencia: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 379.4 °F - closed cup
• Punto de inflamabilidad (°C): 193 °C - closed cup
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves