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M0605000

1,1-Dimetilbiguanida hydrochloride

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Metformina

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About This Item

Fórmula lineal:
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
Número de CAS:
1115-70-4
Peso molecular:
165.62
Número MDL:
MFCD00012582
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329817811
NACRES:
NA.24

grado

pharmaceutical primary standard

Agency

EP Reference standard

familia API

metformin

fabricante / nombre comercial

EDQM

mp

223-226 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

Cl[H].CN(C)C(=N)NC(N)=N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

Clave InChI

OETHQSJEHLVLGH-UHFFFAOYSA-N

Información sobre el gen

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Metformin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

La metformina es un antidiabético que reduce las concentraciones de glucosa en sangre y mejora la sensibilidad a la insulina. Sus efectos metabólicos, entre ellos la inhibición de la gluconeogénesis hepática, están mediados al menos en parte por la activación de la ruta LKB1-AMPK (proteína cinasa activada por AMP). La activación de esta vía también parece estar implicada en las acciones antiproliferativas y proapoptóticas de la metformina en las líneas de células cancerosas.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
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PHR1331

Metformin Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

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Metformin impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001600

Metformin impurity F, European Pharmacopoeia (EP) Reference Standard

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Metformin Related Compound B, United States Pharmacopeia (USP) Reference Standard

1396342

Metformin Related Compound C, United States Pharmacopeia (USP) Reference Standard

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PHR1506

Metformin Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1532

Metformin Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

BP227

1,1-Dimetilbiguanida hydrochloride, British Pharmacopoeia (BP) Reference Standard

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H319

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Yen-Hsiang Chang et al.
Frontiers in endocrinology, 11, 445-445 (2020-08-28)
Background: Plenty of evidence suggested that chronic low-grade inflammation triggered by innate immunity activation contributes to the pathogenesis of type 2 diabetes (T2D). Using the trans-mitochondrial cybrid cell model, we have demonstrated that mitochondria independently take part in the pathological
L C Morin-Papunen et al.
The Journal of clinical endocrinology and metabolism, 85(9), 3161-3168 (2000-09-22)
Metformin, a biguanide antihyperglycemic drug, has been shown to improve ovarian function and glucose metabolism in women with polycystic ovary syndrome (PCOS), but results concerning its effects on insulin sensitivity are controversial. Oral contraceptive pills are commonly used in the
P H Marathe et al.
British journal of clinical pharmacology, 50(4), 325-332 (2000-09-30)
The purpose of this in vivo human study was to assess the effect of altered gastric emptying and gastrointestinal motility on the absorption of metformin in healthy subjects. An open-label, three treatment, three period crossover study was conducted in 11
J De Jager et al.
Journal of internal medicine, 257(1), 100-109 (2004-12-21)
The UK Prospective Diabetes Study (UKPDS) showed that treatment with metformin decreases macrovascular morbidity and mortality independent of glycaemic control. We hypothesized that metformin may achieve this by improving endothelial function and chronic, low-grade inflammation. Data on this issue are
P S Gillies et al.
Drugs, 60(2), 333-343 (2000-09-13)
Pioglitazone is an orally administered insulin sensitising thiazolidinedione agent that has been developed for the treatment of type 2 diabetes mellitus. Pioglitazone activates the nuclear peroxisome proliferator activated receptor-gamma (PPAR-gamma), which leads to the increased transcription of various proteins regulating
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Protocolos

LC/MS Analysis of Melamine and Metformin on Ascentis® Express HILIC

Separation of Melamine; 1,1-Dimethylbiguanide hydrochloride

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