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C9231

Carbenicillin disodium

Name: Carbenicillin disodium
Brand: SIAL

meets USP testing specifications

Sinónimos:

Carbenicillin disodium salt, α-Carboxybenzylpenicillin disodium salt

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About This Item

Fórmula empírica (notación de Hill):

C₁₇H₁₆N₂Na₂O₆S

Número de CAS:

4800-94-6

Peso molecular:

422.36

Beilstein:

5722128

Número CE:

225-360-8

Número MDL:

MFCD00077683

Código UNSPSC:

51102829

ID de la sustancia en PubChem:

24893142

NACRES:

NA.76

Agency

USP/NF
meets USP testing specifications

Nivel de calidad

200

formulario

solid

solubilidad

H₂O: 50 mg/mL

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

aplicaciones

pharmaceutical (small molecule)

Modo de acción

cell wall synthesis | interferes

temp. de almacenamiento

2-8°C

cadena SMILES

[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1

Clave InChI

RTYJTGSCYUUYAL-YCAHSCEMSA-L

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Categorías relacionadas

Antibióticos

Reactivos y suplementos para cultivo celular

Descripción general

Chemical structure: ß-lactam

Aplicación

Used for selection of ampr transformed cells. Used to study the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.

Acciones bioquímicas o fisiológicas

Mode of Action: Carboxypenicillin antibiotic that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Antimicrobial spectrum: Active against Gram-positive and Gram-negative bacteria

Nota de análisis

Stable at 37 °C for 3 days

Otras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

GHS08

Palabra de señalización

Danger

Frases de peligro

H317,H334

Consejos de prudencia

P261 - P280 - P342 + P311

Clasificaciones de peligro

Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Molecular dynamics of class A β-lactamases-effects of substrate binding.

Olivier Fisette et al.

Biophysical journal, 103(8), 1790-1801 (2012-10-23)

The effects of substrate binding on class A β-lactamase dynamics were studied using molecular dynamics simulations of two model enzymes; 40 100-ns trajectories of the free and substrate-bound forms of TEM-1 (with benzylpenicillin) and PSE-4 (with carbenicillin) were recorded (totaling

Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules.

Nina Möker et al.

Journal of bacteriology, 192(7), 1946-1955 (2010-01-26)

Bacterial persister cells constitute a small portion of a culture which is tolerant to killing by lethal doses of bactericidal antibiotics. These phenotypic variants are formed in numerous bacterial species, including those with clinical relevance like the opportunistic pathogen Pseudomonas

Dynamic FtsA and FtsZ localization and outer membrane alterations during polar growth and cell division in Agrobacterium tumefaciens.

John R Zupan et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(22), 9060-9065 (2013-05-16)

Growth and cell division in rod-shaped bacteria have been primarily studied in species that grow predominantly by peptidoglycan (PG) synthesis along the length of the cell. Rhizobiales species, however, predominantly grow by PG synthesis at a single pole. Here we

Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.

Sarah Sainsbury et al.

Journal of molecular biology, 405(1), 173-184 (2010-10-27)

We report the first crystal structures of a penicillin-binding protein (PBP), PBP3, from Pseudomonas aeruginosa in native form and covalently linked to two important β-lactam antibiotics, carbenicillin and ceftazidime. Overall, the structures of apo and acyl complexes are very similar;

Monamphilectine A, a potent antimalarial β-lactam from marine sponge Hymeniacidon sp: isolation, structure, semisynthesis, and bioactivity.

Edward Avilés et al.

Organic letters, 12(22), 5290-5293 (2010-10-23)

Monamphilectine A (1), a new diterpenoid β-lactam alkaloid showing potent antimalarial activity, was isolated in milligram quantities following bioassay-directed extraction of a Puerto Rican marine sponge Hymeniacidon sp. Its structure, established by interpretation of spectral data, was confirmed unequivocally by

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