917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

• Sinónimos: Semi-flexible linker for PROTAC^® development
• Fórmula empírica (notación de Hill): C₁₂H₁₈ClNO
• Número de CAS: 1187927-60-1
• Peso molecular: 227.73
• Número MDL: MFCD11506185
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95%
• formulario: powder
• idoneidad de la reacción: reagent type: linker
• grupo funcional: hydroxyl
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OCC1=CC=C(C2CCNCC2)C=C1.Cl
• InChI: 1S/C12H17NO.ClH/c14-9-10-1-3-11(4-2-10)12-5-7-13-8-6-12;/h1-4,12-14H,5-9H2;1H
• Clave InChI: JSCRYCUDRVBGRN-UHFFFAOYSA-N

Descripción

Aplicación

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Otras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable