916846

2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid

95%

• Sinónimos: Semi-flexible linker for PROTAC^® development
• Fórmula empírica (notación de Hill): C₁₇H₂₃NO₄
• Número de CAS: 170838-26-3
• Peso molecular: 305.37
• Número MDL: MFCD08460729
• Código UNSPSC: 12352106

Propiedades

• Nivel de calidad: 100
• Ensayo: 95%
• Formulario: powder
• idoneidad de la reacción: reagent type: linker
• grupo funcional: Boc; carboxylic acid
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(N(CC1)CCC1C(C=CC=C2)=C2C(O)=O)OC(C)(C)C
• InChI: 1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-12(9-11-18)13-6-4-5-7-14(13)15(19)20/h4-7,12H,8-11H2,1-3H3,(H,19,20)
• Clave InChI: NPKPUCNATSURJQ-UHFFFAOYSA-N

Descripción

Aplicación

2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Otras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H315,H317,H319,H410
• Consejos de prudencia: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable