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Merck
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63175

Sigma-Aldrich

4-Maleimidobutyric acid N-hydroxysuccinimide ester

≥98.0% (HPLC)

Sinónimos:

4-Maleimidobutyric acid N-succinimidyl ester, N-(γ-Maleimidobutyryloxy)succinimide, N-Succinimidyl 4-maleimidobutyrate, GMBS

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About This Item

Fórmula empírica (notación de Hill):
C12H12N2O6
Número de CAS:
80307-12-6
Peso molecular:
280.23
Beilstein:
6427689
Número MDL:
MFCD00036817
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
329759802
NACRES:
NA.25

Nivel de calidad

100

Análisis

≥98.0% (HPLC)

idoneidad de la reacción

reagent type: linker

mp

123-129 °C

grupo funcional

NHS ester

temp. de almacenamiento

2-8°C

cadena SMILES

O=C1N(CCCC(ON2C(CCC2=O)=O)=O)C(C=C1)=O

InChI

1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2

Clave InChI

PVGATNRYUYNBHO-UHFFFAOYSA-N

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Aplicación

A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 7-atom linker.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCBV0406
BCBV3389
SLBH6654
SLBF9915
SLBD5045

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Nature communications, 10(1), 1478-1478 (2019-04-02)
Circulating tumor cells (CTCs) have become an established biomarker for prognosis in patients with various carcinomas. However, current ex vivo CTC isolation technologies rely on small blood volumes from a single venipuncture limiting the number of captured CTCs. This produces
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Journal of the Royal Society, Interface, 9(75), 2457-2467 (2012-05-04)
The specific recognition between monoclonal antibody (anti-human prostate-specific antigen, anti-hPSA) and its antigen (human prostate-specific antigen, hPSA) has promising applications in prostate cancer diagnostics and other biosensor applications. However, because of steric constraints associated with interfacial packing and molecular orientations
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