11162306001

ATP-γ-S

=90% (HPLC), solution, pkg of 200 μL (20 μmol)

• Sinónimos: adenosine-5′-o-(3-thio-triphosphate)
• Código UNSPSC: 12352204

Propiedades

• Nivel de calidad: 100
• descripción: C₁₀H₁₆N₅O₁₂P₃SLi (Formula); Lithium salt
• Análisis: 90% (HPLC)
• formulario: solution
• mol peso: 523.2
• envase: pkg of 200 μL (20 μmol)
• fabricante / nombre comercial: Roche
• λmáx.: 260 nm at 100 mmol/L
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Adenosine 5′-O-(3-thiotriphosphate), lithium salt, solution.

Aplicación

ATP-γ-S has been used:

• to treat THP-1 macrophage cell lines for testing if endoplasmic reticulum (ER) stress causes the production of interleukin (IL)-1β
• in amide hydrogen exchange (HX) experiments coupled to mass spectrometry and study the cyclomarin A (CymA)-induced structural changes in N_Mtb-ClpC
• as a supplement in CMG-binding buffer for gel-based DNA unwinding assays

Acciones bioquímicas o fisiológicas

Adenosine 5′-O-(3-thiotriphosphate) (ATP-γ-S) is a substrate and inhibitor of ATP-dependent enzyme systems. It is hydrolyzed very slowly by phosphatases and most ATPases. Once thiophosphorylated, proteins are resistant to protein phosphatases. ATP-γ-S serves as a damage-associated molecular pattern molecule (DAMP) and NLR family pyrin domain containing 3 (NLRP3) inflammasome activator. ATP-γ-S may serve as a substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eukaryotic initiation factor-4A (eIF4A).

Calidad

Contaminants: ≤10% ADP (HPLC)

Otras notas

For life science research only. Not for use in diagnostic procedures.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): No data available
• Punto de inflamabilidad (°C): No data available