MABN282

Anti-CNGB1 Antibody, clone 5A5.1

clone 5A5.1, 1 mg/mL, from mouse

• Sinónimos: Cyclic nucleotide-gated cation channel beta-1, Cyclic nucleotide-gated cation channel 4, CNG channel 4, CNG-4, CNG4, Cyclic nucleotide-gated cation channel gamma, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 5A5.1, monoclonal
• reactividad de especies: human
• concentración: 1 mg/mL
• técnicas: western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_001129111
• Nº de acceso UniProt: Q14028
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CNGB1(1258)

Descripción

Descripción general

CNGB1, also known as Cyclic nucleotide-gated cation channel beta-1, Cyclic nucleotide-gated cation channel 4 (CNG4), Cyclic nucleotide-gated cation channel gamma, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-1, or Glutamic acid-rich protein (GARP), and encoded by the gene CNGB1/CNCG2/CNCG3L/CNCG4/RCNC2, is a subunit of cyclic nucleotide-gated (CNG) channels which are nonselective cation channels expressed in retinal and olfactory neurons. The CNG channels play important roles in both visual and olfactory signal transduction. When associated with CNGA1, CNGB1 is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. CNGB1 is localized in the plasma membranes of expressing cells and mediates the ion transport of the channel. Mutations in CNGB1 are associated with the genetic disease retinitis pigmentosa 45 that is a progressive vision disease associated with the loss of rod and cone photoreceptors.

Inmunógeno

GST-tagged recombinant protein corresponding to human CNGB1.

Aplicación

Detect CNGB1 using this Anti-CNGB1 Antibody, clone 5A5.1 validated for use in western blotting.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Calidad

Evaluated by Western Blotting in Y79 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CNGB1 in 10 µg of Y79 cell lysate.

Descripción de destino

~140 kDa observed

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable