MABF158C

Anti-CD152 (CTLA-4) (mouse), PE-Cy7, clone UC10-4F10-11 Antibody

clone UC10-4F10-11, from hamster(Armenian), PE-Cy7

• Sinónimos: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), CD152, CD152 (CTLA-4)
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.44

Propiedades

• origen biológico: hamster (Armenian)
• Nivel de calidad: 100
• conjugado: PE-Cy7
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: UC10-4F10-11, monoclonal
• reactividad de especies: mouse
• envase: antibody small pack of 25 μg
• técnicas: flow cytometry: suitable
• isotipo: IgG
• Nº de acceso UniProt: P09793
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: mouse ... Ctla4(12477)

Descripción

Descripción general

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

Aplicación

This armenian hamster monoclonal Anti-CD152 (CTLA-4) Antibody (mouse), PE-Cy7, clone UC10-4F10-11, Cat. No. MABF1586 is validated for use in Flow Cytometry, for the detection of CD152 (CTLA-4).

Calidad

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.

Otras notas

Concentration: Please refer to lot specific datasheet.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable