MAB8126
Anti-Cytomegalovirus Antibody, late Antigen, clone 2D4.2
clone 2D4.2, Chemicon®, from mouse
Sinónimos:
CMV
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
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origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
2D4.2, monoclonal
reactividad de especies
human
fabricante / nombre comercial
Chemicon®
técnicas
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotipo
IgG2a
Condiciones de envío
wet ice
Especificidad
Reacts with a late protein M.W. 47-55 kD. Can detect CMV infection 24 hours post-infection exhibiting a cytoplasmic staining which reduces peak intensity at >72 hours.
With CMV the antigens expressed at different times are listed as:
Immediate Early (alpha gene expression): those antigens expressed at 3-12 hrs post-infection generally involved in Transcription such as 72kD major phosphoprotein and a few other other antigens at 60 - 80kD.
Early Antigen (beta genes) a.k.a. Delayed Early or Intermediate Early: expressed at 12-24hrs post-infection. Generally enzymes and one virion structural gene preceding viral DNA synthesis.
Late Antigen (gamma genes): expressed at 36-48hrs post-infection. Generally structural proteins. Major protein = 55kD
With CMV the antigens expressed at different times are listed as:
Immediate Early (alpha gene expression): those antigens expressed at 3-12 hrs post-infection generally involved in Transcription such as 72kD major phosphoprotein and a few other other antigens at 60 - 80kD.
Early Antigen (beta genes) a.k.a. Delayed Early or Intermediate Early: expressed at 12-24hrs post-infection. Generally enzymes and one virion structural gene preceding viral DNA synthesis.
Late Antigen (gamma genes): expressed at 36-48hrs post-infection. Generally structural proteins. Major protein = 55kD
Inmunógeno
Epitope: late antigen
Sucrose gradient purified CMV AD169 (ATCC).
Aplicación
Anti-Cytomegalovirus Antibody, late antigen, clone 2D4.2 detects level of Cytomegalovirus & has been published & validated for use in IF, WB, IH(P).
IFA at 1:400-1:800 on acetone fixed cells.
Works on paraffin embedded tissue sections.
Dilute with buffer pH 7.4-7.6 to desired working volume.
For extensive dilution, protein containing or other stabilizing medium should be used.
Final working dilutions must be determined by end user.
Works on paraffin embedded tissue sections.
Dilute with buffer pH 7.4-7.6 to desired working volume.
For extensive dilution, protein containing or other stabilizing medium should be used.
Final working dilutions must be determined by end user.
Research Category
Infectious Diseases
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral
Infectious Diseases - Viral
Forma física
Format: Purified
Purified immunoglobulin. Liquid in 0.02M PB with 0.25M NaCl, pH=7.6, 0.1% Sodium Azide.
Almacenamiento y estabilidad
Maintain at +2-8°C for up to 12 months.
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Development of models and detection methods for different forms of cytomegalovirus for the evaluation of viral inactivation agents.
Vasudevacharya Jayarama, Jennifer Marcello, Asa Ohagen, Veronica Gibaja et al.
Transfusion null
Sylwia Libard et al.
PloS one, 9(9), e108861-e108861 (2014-10-01)
Human cytomegalovirus (HCMV) has been indicated being a significant oncomodulator. Recent reports have suggested that an antiviral treatment alters the outcome of a glioblastoma. We analysed the performance of commercial HCMV-antibodies applying the immunohistochemical (IHC) methods on brain sample obtained
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