MABC202
Anti-APC Antibody, clone FE9
clone FE9, from mouse
Sinónimos:
Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
FE9, monoclonal
reactividad de especies
human
técnicas
western blot: suitable
isotipo
IgG1κ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... APC(324)
Descripción general
Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.
Especificidad
This antibody recognizes the N-terminus of APC.
Inmunógeno
Linear peptide corresponding to the N-terminus of human APC.
Aplicación
Anti-APC Antibody, clone FE9 is an antibody against APC for use in Western Blotting.
Calidad
Evaluated by Western Blot in SW480 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected APC in 10 µg of SW480 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected APC in 10 µg of SW480 cell lysate.
Descripción de destino
~147 kDa observed. Uniprot describes the full length protein at ~312 kDa This antibody was shown to detect the truncated form at ~147 kDa
Forma física
Format: Purified
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Inducible in vivo genome editing with CRISPR-Cas9.
Dow, LE; Fisher, J; O'Rourke, KP; Muley, A; Kastenhuber, ER; Livshits, G; Tschaharganeh et al.
Nature Biotechnology null
Thai Q Tran et al.
Nature cancer, 1(3), 345-358 (2020-08-25)
Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumourigenesis. Here, we show that environmental glutamine restriction further augments Wnt signaling in APC mutant intestinal organoids to promote stemness and leads to adenocarcinoma formation
Maria Paz Zafra et al.
Nature biotechnology, 36(9), 888-893 (2018-07-04)
CRISPR base editing enables the creation of targeted single-base conversions without generating double-stranded breaks. However, the efficiency of current base editors is very low in many cell types. We reengineered the sequences of BE3, BE4Gam, and xBE3 by codon optimization
Bo Cen et al.
Oncogene, 40(41), 5984-5992 (2021-08-14)
PD-L1 expression is elevated in various human cancers, including colorectal cancer. High levels of PD-L1 expressed on tumor epithelial cells are one of the potential mechanisms by which tumor cells become resistant to immune attack. However, PD-L1 regulation in tumor
Dong Hoon Kang et al.
Nature communications, 8(1), 40-40 (2017-07-01)
Mammalian 2-Cys peroxiredoxin (Prx) enzymes are overexpressed in most cancer tissues, but their specific signaling role in cancer progression is poorly understood. Here we demonstrate that Prx type II (PrxII) plays a tumor-promoting role in colorectal cancer by interacting with
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