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Key Documents

MAB2021Z

Sigma-Aldrich

Anti-Integrin αV Antibody, extracellular, clone AV1, azide free

culture supernatant, clone AV1, Chemicon®

Sinónimos:

CD51, VitronectinReceptor, MAB2021

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

mouse

Nivel de calidad

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

AV1, monoclonal

reactividad de especies

human

fabricante / nombre comercial

Chemicon®

técnicas

flow cytometry: suitable
western blot: suitable

isotipo

IgG1

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... ITGAV(3685)

Especificidad

Specific for human integrin alphaV (other species not tested).

Inmunógeno

Epitope: extracellular, azide free
Human integrin alphaVbeta3 heterodimer isolated from placenta.

Aplicación

Anti-Integrin αV Antibody, extracellular, clone AV1, azide free detects level of Integrin αV & has been published & validated for use in FC & WB.
Flow cytometry: 1:5-1:50

Western Blot. Under non-reducing conditions recognizes a band at approximately 165 kDa corresponding to integrin alphaV. Does not recognize the reduced protein.

Function-blocking of integrin alphaV-mediated adhesion to ECM proteins. (1:5-1:20, in HEPES buffer pH 7.4 containing 1mM Mn++ and 1mM Mg++).

Optimal working dilutions and protocols must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Forma física

Unpurified tissue culture supernatant from a perfusion system, filtered through a 0.2μ micron membrane prior to vialing. Product contains 20%FBS and Ciprofloxacin at final concentration of 10μg/mL.

Almacenamiento y estabilidad

Maintain at 2-8°C in undiluted aliquots for up to 12 months.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container′s cap.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Bourne, SP et al.
Journal of Neuro-Oncology, 10, 111-119 (1991)
Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism.
Yannick D Benoit,Carine Lussier,Pierre-Alexandre Ducharme,Sophie Sivret,Lynn M Schnapp et al.
Biology of the Cell null
Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells.
Yannick D Benoit,Jean-Francois Larrivee,Jean-Francois Groulx,Jana Stankova et al.
Biochemical and biophysical research communications null
Human metapneumovirus (HMPV) binding and infection are mediated by interactions between the HMPV fusion protein and heparan sulfate.
Chang, A; Masante, C; Buchholz, UJ; Dutch, RE
Journal of virology null
Integrin alphavbeta1 promotes infection by human metapneumovirus.
Cseke, G; Maginnis, MS; Cox, RG; Tollefson, SJ; Podsiad, AB; Wright, DW; Dermody, TS; Williams, JV
Proceedings of the National Academy of Sciences of the USA null

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