ABT61

Anti-INF2 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Inverted formin-2, HBEBP2-binding protein C
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: rat, human
• técnicas: immunohistochemistry: suitable (paraffin); western blot: suitable
• Nº de acceso NCBI: NP_071934
• Nº de acceso UniProt: Q27J81
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... INF2(64423)

Descripción

Descripción general

INF2 (inverted formin 2) is a mouse formin that has been found to interact with actin through the C-terminus to the formin homology 2 domain. The WASP homology 2 motif activates another region that appropriates actin monomers. INF2 has a unique ability to speed up polymerization and depolymerization of actin filaments. Mutations in the N-terminal diaphanous inhibitory domain of INF2 have been proven to be a main cause of familial focal segmental glomerulosclerosis.

Especificidad

Other homologies: Mouse (68% sequence homology).

Inmunógeno

KLH-conjugated linear peptide corresponding to human INF2.

Aplicación

Anti-INF2 Antibody is an antibody against INF2 for use in WB, IH(P).

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot of this antibody detected INF2 in stomach cancer tissue.

Research Category
Cell Structure

Research Sub Category
Cytoskeletal Signaling

Calidad

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected INF2 in 10 µg of HeLa cell lysate.

Descripción de destino

~155 kDa observed.
INF2 has been shown in WB to migrate as an ~155 kDa band (Madrid, R., et al. (2010). Dev Cell. 18(5):814-827).
Uniprot describes 3 isoforms produced by alternative splicing with MW′s @ ~135, ~134 & ~25 kDa

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl and 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
HeLa cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable