ABS85

Anti-CPT2 Antibody

serum, from rabbit

• Sinónimos: Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: serum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• reactividad de especies: rat
• reactividad de especies (predicha por homología): human (immunogen homology)
• técnicas: western blot: suitable
• isotipo: IgG
• Nº de acceso NCBI: NP_000089
• Nº de acceso UniProt: P23786
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CPT2(1376)

Descripción

Descripción general

Carnitine palmitoyltransferase II (CPT2, or CPT II) belongs to the carnitine/choline acetyltransferase family. It is a ubiquitous protein found in the inner membrane of the mitochondria and plays an essential role in fatty acid β-oxidation. CPT2 is part of the system involving CPT1 and carnitine/acylcarnitine translocase (CACT), that facilitate the transport of long chain fatty acids into the mitochondrial matrix. CPT2 plays the role of restoring these molecules to original esterified forms suitable for β-oxidation, after they arrive in the matrix. Defects in CPT2 has varying outcomes: in adults, it results in episodes of rhabdomyolysis (breakdown of muscle fibers which circulate in the bloodstream), after prolonged and vigorous exercise; and in infants, CPT2 deficiency induces hypoketotic hypoglycemia and eventual cardiac damage.

Inmunógeno

KLH-conjugated linear peptide corresponding to human CPT2.

Aplicación

Anti-CPT2 detects levels of CPT2 proteins & has been published & validated for use in WB.

Calidad

Evaluated by Western Blot in rat liver mitochondria tissue lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected CPT2 on 10 µg of rat liver mitochondria tissue lysate.

Descripción de destino

~68 kDa observed (cleaved form). Uniprot gives a calculated weight of 74 kDa; however, CPT2 has been observed at ~68 kDa (Faye, A, et al. (2007). The Journal of Biological Chemistry. 282(37):26908–26916.). Uncharacterized bands appear at ~55, 58, 72, and 100 kDa in some lysates.

Nota de análisis

Control
Rat liver mitochondria tissue lysate

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1