ABS763

Anti-DPAGT1 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: mouse
• técnicas: western blot: suitable
• Nº de acceso UniProt: Q9H3H5
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... DPAGT1(1798)

Descripción

Descripción general

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, also known as GlcNAc-1-P transferase (G1PT or GPT) or N-acetylglucosamine-1-phosphate transferase, and encoded by the gene name DPAGT1 or DPAGT2, is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. Mutations in this integral endoplasmic reticulum (ER) membrane protein enzyme belongs to the glycosyltransferase family 4 results in the congenital disorder of glycosylation type Ij with symptoms such as severe hypotonia, medically intractable seizures, mental retardation, microcephaly, and exotropia. Recent experiments have shown that DPAGT1 is a target of the Wnt/beta-catenin signaling pathway, with Wnt3a inducing higher DPAGT1 mRNA expression.

Inmunógeno

Epitope: N-terminus

KLH-conjugated synthetic peptide corresponding to the N-terminus of human DPAGT1.

Aplicación

Anti-DPAGT1 Antibody detects level of DPAGT1 & has been published & validated for use in DPAGT1.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Calidad

Evaluated by Western Blotting in mouse kidney tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected DPAGT1 in mouse kidney tissue lysate with and without blocking peptide.

Descripción de destino

~42 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable