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ABN645

Sigma-Aldrich

Anti-RIM 2 Antibody

from rabbit, purified by affinity chromatography

Sinónimos:

Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2, Rab-3-interacting protein 3

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
clon:
polyclonal
application:
IF
IHC
WB
reactividad de especies:
rat, human
técnicas:
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
citations:

origen biológico

rabbit

Nivel de calidad

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

purificado por

affinity chromatography

reactividad de especies

rat, human

técnicas

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

Nº de acceso UniProt

Condiciones de envío

wet ice

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... RIMS2(9699)

Descripción general

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM 1 and RIM 2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM 1, RIM 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

Especificidad

This antibody may recognize many isoforms and is predicted to have no cross-reactivity to other RIM proteins.

Inmunógeno

Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human RIM 2.

Aplicación

Anti-RIM 2 Antibody is an antibody against RIM 2 for use in western blotting, IHC & immunofluorescence.
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected RIM 2 in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected RIM 2 in human brain cells.



Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Calidad

Evaluated by Western Blotting in rat brain tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected RIM 2 in rat brain tissue lysate with and without blocking peptide.

Descripción de destino

~86 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing ranging between ~31 kDa and ~160 kDa

Forma física

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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