ABC338

Anti-IRGM Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: IRGM Antibody, Immunity related GTPase family, IFL1, IRGM1, LRG47, LRG-47
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: human
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• Nº de acceso UniProt: A1A4Y4
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... IRGM(345611)

Descripción

Descripción general

Immunity-related GTPase family M protein (IRGM), also known as Interferon-inducible protein 1 (IFI1) and LPS-stimulated RAW 264.7 macrophage protein 47 homolog (LRG-47), is a member of the interferon-inducible GTPase family. It induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. IRGM is expressed in colon, small bowel, and peripheral blood leukocytes. Mutations in IRGM have been assoicated with inflammatory bowel disease type 19 which is subdivided into Crohn′s disease and ulcerative colitis phenotypes.

Especificidad

This antibody recognizes the intermediate domain of IRGM.

Inmunógeno

KLH-conjugated linear peptide corresponding to the intermediate domain of human IRGM.

Aplicación

Detect Immunity-related GTPase family M protein using this rabbit polyclonal antibody, Anti-IRGM Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected IRGM in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IRGM in human brain cells.

Calidad

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected IRGM in 15 µg of human brain tissue lysate.

Descripción de destino

~31 kDa observed. Uncharacterized bands may appear in some lysates.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable