ABC20

Anti-Cystatin-C Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Cystatin-C, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: mouse, human, rat
• técnicas: immunohistochemistry: suitable (paraffin); western blot: suitable
• Nº de acceso NCBI: NP_000090
• Nº de acceso UniProt: P01034
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified

Descripción

Descripción general

Cystatin-C is a cysteine protease inhibitor in mammals, which is essential in protein degradation and keeping an equilibrium between inhibitors and proteases. It is thought to be a better marker for renal dysfunction and potential kidney injury than creatinine. Recently, Cystatin-C has been implicated in primary hypertension and may be a novel marker in patients. Cystatin-C has also been implicated in oxidative stress-induced apoptosis of CNS neurons and has been shown to inhibit amyloid-beta deposition in Alzheimer′s disease models.

Inmunógeno

KLH-conjugated linear peptide corresponding to human Cystatin-C.

Aplicación

Anti-Cystatin-C Antibody detects level of Cystatin-C & has been published & validated for use in WB, IH(P).

Immunohistochemistry (paraffin) Analysis: A 1:1000 dilution of a previous lot detected Cystatin-C in purkinje cells of normal rat cerebellum, neurons of normal rat frontal lobe, and neurons in normal rat midbrain.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Neurodegenerative Diseases

Calidad

Evaluated by Western Blot in human kidney tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Cystatin-C in 10 µg of human kidney tissue lysate.

Descripción de destino

~14 kDa observed.
An uncharacterized band may appear at ~62 kDa in some lysates.

Forma física

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Human kidney tissue lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable