AB5058
Anti-Prion Protein Antibody, NT, a.a. 78-97
serum, Chemicon®
Sinónimos:
PrP, CD230
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.43
origen biológico
goat
Nivel de calidad
forma del anticuerpo
serum
tipo de anticuerpo
primary antibodies
clon
polyclonal
reactividad de especies
human
fabricante / nombre comercial
Chemicon®
técnicas
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... PRNP(5621)
Especificidad
Specific for human prion protein (PrP). This antibody immunolabels amyloid plaques in formalin-fixed paraffin sections from Creutzfeld-Jakob Disease (CJD) brain.The prion protein is a large membrane protein that occurs normally in neurons of the human brain and is thought to be involved in synaptic transmission. In prion diseases, such as CJD, Gerstmann-Straussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered protein when it comes into contact with an infectious prion protein (PrPsc) from another host. This altered PrPsc accumulates in cytoplasmic vesicles of diseased individuals forming lesions, vacuoles and amyloid deposits.
Inmunógeno
Epitope: N-terminus, a.a. 78-97
Synthetic peptide that corresponds to amino acids 79-97 of the N-terminus of the human PrP27-30.
Aplicación
Anti-Prion Protein Antibody, N-terminus, a.a. 78-97 detects level of Prion Protein & has been published & validated for use in ELISA, WB, IH(P).
Immunohistochemistry: >1:200 on paraffin embedded, formalin fixed human brain.
Western blots: >1:2,000
ELISA: >1:35,000
Optimal working dilutions must be determined by the end user.
Western blots: >1:2,000
ELISA: >1:35,000
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Forma física
Goat serum. Liquid containing 0.01% thimerosal
Almacenamiento y estabilidad
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Copper has differential effect on prion protein with polymorphism of position 129.
B S Wong, C Clive, S J Haswell, R A Williamson, D R Burton, P Gambetti, M S Sy, I M Jones, D R Brown
Biochemical and biophysical research communications null
Toluidine blue-O staining of prion protein deposits.
A Sanchez, A Guzman, A Ortiz, D Rembao, B Espinosa, E Zenteno, J Guevara
Histochemistry and Cell Biology null
Selective oxidation of methionine residues in prion proteins.
B S Wong, H Wang, D R Brown, I M Jones
Biochemical and biophysical research communications null
Molecular and genetic features of a labeled class of spinal substantia gelatinosa neurons in a transgenic mouse.
Adam W Hantman, Edward R Perl
The Journal of Comparative Neurology null
Creutzfeldt-Jakob disease in Mexico.
Leora Velasquez-Perez, Daniel Rembao-Bojorquez, Jorge Guevara et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology null
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