8.17058

Maleic acid

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Sinónimos: cis-Butenedioic acid, Toxilic acid
• Fórmula lineal: HO₂CCH=CHCO₂H
• Número de CAS: 110-16-7
• Peso molecular: 116.07
• Beilstein: 605762
• Número MDL: MFCD00063177
• Código UNSPSC: 12352106
• Número índice de la CE: 203-742-5

Propiedades

• Agency: NF; Ph. Eur.
• Nivel de calidad: 500
• presión de vapor: <0.1 hPa ( 20 °C)
• Línea del producto: EMPROVE^® ESSENTIAL
• Análisis: 99.0-101.0% substance (anhydrous) basis
• formulario: solid
• potencia: 708 mg/kg LD₅₀, oral (Rat); 1560 mg/kg LD₅₀, skin (Rabbit)
• técnicas: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 1.3 (20 °C, 100 g/L in H₂O)
• mp: 130-135 °C (lit.)
• solubilidad: 478.8 g/L
• densidad: 1.59 g/mL at 25 °C (lit.)
• trazas de catión: Fe: ≤5 ppm; V: ≤1 ppm; heavy metals (as Pb): ≤10 ppm
• aplicaciones: liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• temp. de almacenamiento: 15-25°C
• cadena SMILES: OC(=O)\C=C/C(O)=O
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
• Clave InChI: VZCYOOQTPOCHFL-UPHRSURJSA-N

Descripción

Descripción general

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Maleic acid is typically used as pH adjuster or buffer agent in pharmaceutical formulations. Maleic acid Emprove^® Essential is mainly used in highly regulated pharmaceutical applications.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS05,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302 + H312,H314,H317,H335
• Consejos de prudencia: P260 - P271 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 8A - Combustible corrosive hazardous materials
• Clase de riesgo para el agua (WGK): WGK 1