596200

Thioflavin T

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils.

• Sinónimos: Thioflavin T, ThT, Thioflavine T, Basic Yellow 1
• Fórmula empírica (notación de Hill): C₁₇H₁₉ClN₂S
• Número de CAS: 2390-54-7
• Peso molecular: 318.86
• Número MDL: MFCD00011944
• Código UNSPSC: 12171500
• NACRES: NA.25

Propiedades

• Nivel de calidad: 100
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: water: 5 mg/mL
• fluorescencia: λ_ex ~385 nm (free); λ_ex ~437 nm; λ_em ~445 nm (free); λ_em ~485 nm
• Condiciones de envío: ambient
• temp. de almacenamiento: 15-25°C
• cadena SMILES: S1c2c(ccc(c2)C)N(C1=C3C=CC(=[N+](C)C)C=C3)C.[Cl-]
• InChI: 1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
• Clave InChI: JADVWWSKYZXRGX-UHFFFAOYSA-M

Descripción

Descripción general

A cell-permeable benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils. Useful in monitoring stacked β sheet aggregates. Associates with aggregated fibrils of synthetic β/A4-derived peptides β(1-28) and β(1-40), resulting in a shift in the excitation maximum and an enhanced emission. Excitation max.: ~385 nm (free); ~437 nm (bound); emission max.: ~445 nm (free); ~485 nm (bound).

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Exhibits enhanced fluorescence upon binding to amyloid fibrils

Product does not compete with ATP.

Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Tjernberg, L.O., et al. 1999. J. Biol. Chem.274, 12619.
Naiki, H. and Nakakuki, K. 1996. Lab. Invest.74, 374.
LeVine, H. 1993. Protein Sci.2, 404.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS05,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H301,H317,H318,H410
• Consejos de prudencia: P261 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable