582243
Tetanus Toxin, Clostridium tetani
Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Código UNSPSC:
12352200
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Formulario
lyophilized
fabricante / nombre comercial
Calbiochem®
disponibilidad
not available in Canada,
condiciones de almacenamiento
OK to freeze
temp. de almacenamiento
2-8°C
Descripción general
Produced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Produced by the anaerobic bacillus Clostridium tetani, Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (~100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (~50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.
Acciones bioquímicas o fisiológicas
Binds GT1b ganglioside in a hemagglutination assay
Primary Target
Tetanus toxin is one of the deadliest toxins known
Tetanus toxin is one of the deadliest toxins known
Product does not compete with ATP.
Advertencia
Toxicity: Highly Toxic (H)
Reconstitución
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Please refer to the vial label for lot-specific reconstitution volume.
Nota de análisis
Single band by SDS-PAGE
Otras notas
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
Información legal
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1
Órganos de actuación
Central nervous system
Código de clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Clase de riesgo para el agua (WGK)
WGK 3
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico