567022

Simvastatin sodium salt

≥95% (HPLC), liquid, L-type calcium channel blocker, Calbiochem^®

• Sinónimos: InSolution Simvastatin, Sodium Salt, L-Type Calcium Channel Blocker VI
• Fórmula empírica (notación de Hill): C₂₅H₃₉O₆ · Na
• Peso molecular: 458.56
• Código UNSPSC: 51111800
• NACRES: NA.77

Propiedades

• product name: Simvastatin, Sodium Salt, InSolution, ≥95%
• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Condiciones de envío: ambient
• temp. de almacenamiento: −70°C

Descripción

Descripción general

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of Simvastatin, Sodium Salt (Cat. No. 567021) is also available.

Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Forma física

A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H₂O.

Reconstitución

Following initial thaw, aliquot and freeze (-70°C).

Otras notas

Yada, T., et al. 1999. Br. J. Pharmacol.126, 1205.
Clutterbuck, R.D., et al. 1998. Br. J. Haematol.102, 522.
Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol.94, 87.
Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta1345, 259.
Vrtovsnik, F., et al. 1997. Kidney Int.52, 1016.
Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable