551590

Quercetagetin

A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM).

• Sinónimos: Quercetagetin, 3,3ʹ,4ʹ,5,6,7-Hexahydroxyflavone
• Fórmula empírica (notación de Hill): C₁₅H₁₀O₈
• Número de CAS: 90-18-6
• Peso molecular: 318.24
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow to yellow-green
• solubilidad: DMSO: 10 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
• Clave InChI: ZVOLCUVKHLEPEV-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC₅₀ = 3.45 µM), and little activity toward c-Abl even at concentrations as high as 200 µM. Inhibits cellular BAD phosphorylation (IC₅₀ = 5.5 µM) and induces growth arrest (ED₅₀ = 3.8 µM) in PIM1-expressing RWPE2 cells.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
PIM1 kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 340 nM against PIM1 kinase

Envase

Packaged under inert gas

Advertencia

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Holder, S., et al. 2007. Mol. Cancer Ther.6, 163.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable