539695

PME-1 Inhibitor, AMZ-30

The PME-1 Inhibitor, AMZ-30 controls the biological activity of PME-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinónimos: PME-1 Inhibitor, AMZ-30, ( E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile, NIH Probe ML136
• Fórmula empírica (notación de Hill): C₁₉H₁₃FN₃O₆S₂
• Peso molecular: 462.45
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥97% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: 50 mg/mL
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable sulfonyl acrylonitrile compound that acts as a potentand irreversible inhibitor of protein phosphatase methylesterase-1(PME-1; IC₅₀ = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells.

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable